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[Peterwem]

Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

[Ernestcok]

‘We don’t want the American Dream for our kids’: Why this couple left the US for Ecuador with their children four years ago
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They’d never even visited Ecuador before, but Brittany and Blake Bowen, from the United States, decided to move to the South American country in 2021 to give their four children a completely different upbringing.

The Bowens, who were previously based in the state of Washington, have been living in Loja, a small city based in the southern section of the Andes Mountains, ever since, and say that they are in it for the long haul.

“We love this little country,” Brittany tells CNN Travel. “We hope that maybe we’ll have grandkids here one day.”
Before the move, the couple, who’ve been married for nearly 17 years, say that they were becoming increasingly concerned about the pressures placed on children by “modern American society” and wanted to try something new.

“We did not like what we’d seen develop over the course of the last couple decades…” adds Brittany, explaining that they felt that young people in the United States were becoming “more isolated.”

“We weren’t confident that our kids would enjoy the same sort of potential trajectory that previous generations had shared.

“And the more we considered things like that, the more we wondered, ‘Is that even what we want? Do we even want them to be on a fast track to the American Dream?”

The couple were also frustrated with living what they describe as the “standard American life.”

“Long commutes and never enough money,” says Blake. “All those usual problems… I was working in a career that was very time consuming, and took me away from home a lot. So we didn’t want that anymore.”

So why did they choose Ecuador as their “new home”?

[JohnnietrIle]

Curiosity rover makes ‘arguably the most exciting organic detection to date on Mars’
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The NASA Curiosity rover has detected the largest organic molecules found to date on Mars, opening a window into the red planet’s past. The newly detected compounds suggest complex organic chemistry may have occurred in the planet’s past — the kind necessary for the origin of life, according to new research.

The organic compounds, which include decane, undecane and dodecane, came to light after the rover analyzed a pulverized 3.7 billion-year-old rock sample using its onboard mini lab called SAM, short for Sample Analysis at Mars.

Scientists believe the long chains of molecules could be fragments of fatty acids, which are organic molecules that are chemical building blocks of life on Earth and help form cell membranes. But such compounds can also be formed without the presence of life, created when water interacts with minerals in hydrothermal vents.

The molecules cannot currently be confirmed as evidence of past life on the red planet, but they add to the growing list of compounds that robotic explorers have discovered on Mars in recent years. A study detailing the findings was published Monday in the journal Proceedings of the National Academy of Sciences.
The detection of the fragile molecules also encourages astrobiologists that if any biosignatures, or past signs of life, ever existed on Mars, they are likely still detectable despite the harsh solar radiation that has bombarded the planet for tens of millions of years.

“Ancient life, if it happened on Mars, it would have released some complex and fragile molecules,” said lead study author Dr. Caroline Freissinet, research scientist at the French National Centre for Scientific Research in the Laboratory for Atmospheres, Observations, and Space in Guyancourt, France. “And because now we know that Mars can preserve these complex and fragile molecules, it means that we could detect ancient life on Mars.”

[LeonardNah]

Everyone is talking about Greenland. Here’s what it’s like to visit
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A few months ago, Greenland was quietly getting on with winter, as the territory slid deeper into the darkness that envelops the world’s northerly reaches at this time of year.

But President Donald Trump’s musings about America taking over this island of 56,000 largely Inuit people, halfway between New York and Moscow, has seen Greenland shaken from its frozen Arctic anonymity.

Denmark, for whom Greenland is an autonomous crown dependency, has protested it’s not for sale. Officials in Greenland, meanwhile, have sought to assert the territory’s right to independence.

The conversation continues to intensify. A contentious March 28 visit to a US military installation by Usha Vance, the second lady, accompanied by her husband, Vice President JD Vance, was the latest in a series of events to focus attention on Trump’s ambitions for Greenland.

The visit was originally planned as a cultural exchange, but was shortened following complaints from Greenland Prime Minister Mute B. Egede.

Had the Vances prolonged their scheduled brief visit, they would’ve discovered a ruggedly pristine wildernesses steeped in rich Indigenous culture.

An inhospitable icecap several miles deep covers 80% of Greenland, forcing the Inuit to dwell along the shorelines in brightly painted communities. Here, they spend brutally cold winters hunting seals on ice under the northern lights in near perpetual darkness. Although these days, they can also rely on community stores.

The problem for travelers over the years has been getting to Greenland via time-consuming indirect flights. That’s changing. Late in 2024, the capital Nuuk opened a long-delayed international airport. From June 2025, United Airlines will be operating a twice-weekly direct service from Newark to Nuuk.

Two further international airports are due to open by 2026 — Qaqortoq in South Greenland and more significantly in Ilulissat, the island’s only real tourism hotspot.

[Kevinsog]

A long time in the making
Curiosity landed in Gale Crater on August 6, 2012. More than 12 years later, the rover has driven over 21 miles (34 kilometers) to ascend Mount Sharp, which is within the crater. The feature’s many layers preserve millions of years of geological history on Mars, showing how it shifted from a wet to a dry environment.
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Perhaps one of the most valuable samples Curiosity has gathered on its mission to understand whether Mars was ever habitable was collected in May 2013.

The rover drilled the Cumberland sample from an area within a crater called Yellowknife Bay, which resembled an ancient lake bed. The rocks from Yellowknife Bay so intrigued Curiosity’s science team that it had the rover drive in the opposite direction to collect samples from the area before heading to Mount Sharp.
Since collecting the Cumberland sample, Curiosity has used SAM to study it in a variety of ways, revealing that Yellowknife Bay was once the site of an ancient lake where clay minerals formed in water. The mudstone created an environment that could concentrate and preserve organic molecules and trapped them inside the fine grains of the sedimentary rock.

Freissinet helped lead a research team in 2015 that was able to identify organic molecules within the Cumberland sample.

The instrument detected an abundance of sulfur, which can be used to preserve organic molecules; nitrates, which are essential for plant and animal health on Earth; and methane composed of a type of carbon associated with biological processes on Earth.

“There is evidence that liquid water existed in Gale Crater for millions of years and probably much longer, which means there was enough time for life-forming chemistry to happen in these crater-lake environments on Mars,” said study coauthor Daniel Glavin, senior scientist for sample return at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, in a statement.

[Author]

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